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Why Recovery?
Over the past 30 years medical studies have definitively established the profound benefits perioperative nutritional supplementation has on surgical outcomes. Immuno-nutrition, a specific combination of amino acids and omega-3 fatty acids, drastically decrease complications such as surgical site infections and poor wound healing. These benefits are irrespective regardless of a patient’s nutritional status. The use of immuno-nutrition has now become a consensus recommendation by several major surgical societies. Historically, immuno-nutrition has not been routinely used because an evidence-based, palatable, shelf-stable, and convenient product did not exist. Until now. Proven Recovery® combines immuno-nutrition with up-to-date evidenced-based compounds to aid in every aspect of patient’s recovery, including improved wound healing, muscle atrophy protection, and infection prevention. Combined, this leads to a lower risk of complications and an accelerated recovery.
Company Overview
Proven Therapeutics™ is a pharmaconutrition company founded by two Canadian Medical Doctors for the purpose of providing patients with safe, evidence-based, medical grade nutrition. Our first-in-class product, Proven Recovery® is a 100% evidence-based pharmaco-nutrition product specifically designed to prepare and improve patients’ recovery from surgery. Proven Recovery® is the only true evidence-based pharmaco-nutrition product on the market.
Each component in Proven Recovery® has been thoroughly researched and their efficacy verified in multiple human peer-reviewed studies (see bibliography). Proven Recovery® is proudly produced in Canada in a GMP-certified facility where it undergoes third party testing prior to distribution. Proven Recovery® has received both Health Canada Approval and FDA clearance. In addition to being the only true pharmaco-nutrition supplement, it is also the only medical grade nutritional supplement with Health Canada Approval and FDA clearance.
Evidence-based immuno-nutrition
The evidence that immuno-nutrition improves recovery from surgery is irrefutable1,2,3,4,5,6,7,8. The medical literature consistently demonstrates that immuno-nutrition lowers the rates of major complications such as infection and prolonged wound healing, while simultaneously accelerating functional outcomes by reducing muscle atrophy and reducing acute and chronic pain. These benefits are realized irrespective of a patient’s pre-existing nutritional status, specifically immuno-nutrition has been shown to be beneficial in plastic and reconstructive, orthopaedic, cardiac, cancer, bariatric, trauma, and general surgery.
First-in-class pharmaconutrition
Building on a foundation of immuno-nutrition, Proven Recovery® has gone farther to become a first-in-class evidence-based pharmaconutrition supplement. Through reverse engineering, Proven Recovery® was designed to specifically target the molecular pathways responsible for multiple aspects of recovery such as muscle atrophy, infection, analgesia, and wound healing. The Pillars of Recovery represent all the ways in which Proven Recovery® works to accelerate the recovery process.
Pillars of Recovery
Bone
Health
Infection Prevention
Accelerated Recovery
Gut Muscle
Axis
Neural
Protection
Analgesia
Anti-Inflammatory
Wound Healing
Atrophy
Protection
Circadian
Rhythm
Consensus Recommendations
The evidence that immuno-nutrition improves outcomes has become so overwhelming it is now included in the consensus recommendations of major perioperative guidelines9,10,11,12.
“All patients presenting for major surgery regardless of nutritional status risk take immuno-nutrition for 7 days prior to surgery and for up to 4 weeks after.”
Duke Perioperative Enhancement Team (POET)
“Supplementing with immunonutrition reduces rates of infection and length of stay in patients regardless of their pre-existing nutritional state.”
Consensus recommendations from American Society for Parenteral and Enteral Nutrition (ASPEN) guidelines
“…strongly recommends immuno-nutrition and recognizes that “arginine-supplemented diets” are associated with a 42% decreased risk of infectious complications. ”
Strong for Surgery, a pre-habilitation initiative created by the American College of Surgeons
“Over 83% of general surgeons believe existing data supports perioperative nutrition to reduce postoperative complications.”
Wischmeyer PE et al., American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Nutrition Screening and Therapy Within a Surgical Enhanced Recovery Pathway. Anesth Analg. 2018 Jun;126(6):1883-1895
Cost Effectiveness
The medical literature has shown immuno-nutrition to be incredibly cost effective. Cost savings are the result of decreased length of hospital stay, readmissions, and decreased complications (i.e. infections). These benefits have been realized in numerous healthcare systems across a range of surgeries, patient populations and clinical environments13,14,15,16.
“For every $1 spent on immuno-nutrition a savings of $52.63 was realized.”
Philipson et. al., Impact of oral nutritional supplementation on hospital outcomes. Am J Manag Care. 2013 Feb;19.
“Cost effectiveness of (immuno-nutrition) could be even greater by accounting for the indirect and socioeconomic costs such as sick leave, rehabilitation, and full recovery of physical and social functioning.”
Strickland A., et al. Is the use of specialized nutritional formulations a cost-effective strategy?
A national database evaluation. JPEN J Parenter Enteral Nutr. 2005 Jan-Feb;29.
How to use Proven Recovery®
Proven Recovery® should ideally be started 5 days before surgery and taken for 5 days after. The product is taken twice a day, in the morning and afternoon, between meals. Mix 1 scoop of Proven Recovery® with 1 cup (200-250ml) of cold water. Drink immediately after reconstituting and rinse mouth out after use.
For larger procedures (i.e. total joint arthroplasty or laparotomy) it is recommend that two courses of Proven Recovery® be utilized. It should be started 5 days before surgery and taken for 15 days after. Additional courses can be prescribed at the discretion of the physician.
Which patients should not take Proven Recovery®?
Kidney Disease
As some patients with kidney disease are required to follow a low protein diet, we suggest that patients with renal disease discuss the risk and benefits of taking Proven Recovery® with their physician prior to use.
Pregnancy & Breast feeding
Although not specifically contraindicated, these products have not been tested in pregnancy or lactating women. It is suggested that women who are pregnant or lactating consult with their physician prior to using Proven Recovery®.
Quality Manufacturing
Each component in Proven Recovery® has been thoroughly researched and their safety and efficacy have been verified in multiple human peer-reviewed studies. The final product is produced in Canada in a GMP-certified facility where it is third party tested prior to shipping.
Proven Recovery® has received Health Canada Approval and FDA Clearance. EMA (European Medicines Agency) approval is pending.
Product Specifications
- Small volume/weight (~340g)
- Flexible polyurethane bag with calibrated scoop included
- Shelf-life stability >2 years
- Small serving size (~18g) to be reconstituted in 200-250ml of water
- Non-genetically modified ingredients, lactose free, daily free, halal, and kosher
Product Components
|
Medical ingredients* Ingrédients médicinaux Serving size 1 scoop / Portion de 1 cuillère |
|
|
Ingredient Ingrédient |
Amount per serving Quantité par portion |
| Creatine Monohydrate / Monohydrate de créatine | 2500mg |
| L-Leucine / L-leucine | 2500 mg |
| L-Valine / L-valine | 1750 mg |
| L-Lysine / L-lysine | 1330 mg |
|
Calcium hydroxymethylbutyrate / Hydroxyméthylbutyrate de calcium |
1500 mg |
| Taurine / Taurine | 1500mg |
| Omega-3 Lysine salt | 500mg |
| L-Isoleucine / L-isoleucine | 1100mg |
| Ascorbic Acid (Vitamin C) / Acide ascorbique (vitamine C) | 1000mg |
|
Soy Lecithin (Phosphatidylcholine) / Lécithine de soja (phosphatidylcholine) |
100mg |
|
L-Citrulline DL-Malate / DL-malate de L-citrulline |
500mg |
| L-Glycine / L-glycine | 350mg |
| L-Methionine / L-méthionine | 250mg |
| L-Arginine / L-arginine | 1250mg |
| L-Glutamine / L-glutamine | 250mg |
| L-Phenylalanine / L-phenylalanine | 150mg |
| L-Threonine / L-thréonine | 75mg |
| Tryptophan / Tryptophane | 110mg |
| L-Histidine / L-histidine | 110mg |
| Quercetin / Quercétine | 100mg |
| Zinc Citrate / Citrate de zinc | 6mg |
| Vitamin B6 (Pyridoxine) / Vitamine B6 (pyridoxine) | 18.2mg |
| Vitamin B1 (Thiamine) / Vitamine B1 (thiamine) | 16.8mg |
| Vitamin D3 (Lichen vegan source) / Vitamine D3 (source végétalienne de lichen) | 12.5mcg |
| Vitamin B12 (Methyl-cobalamin) / Vitamine B12 (méthylcobalamine) | 38.6mcg |
Non-medical ingredients: Citric Acid 400mg, Calcium citrate 200mg, Magnesium citrate 165mg, Sodium chloride 100mg, Sucralose 150mg, natural flavoring. *Ingredient components/amount/sources subject to change.
Summary
Peri-operative immuno-nutrition has definitively been shown to reduce surgical complications, improve patient outcomes and be a safe, cost-effective approach to improving the delivery of healthcare. The tangible cost savings are the results of shorter hospital stay, decreased rate and severity of complications (i.e. infectious and non-infectious), and reduced risk of readmission.
Proven Recovery® is a first-in-class pharmaconutrition product. It builds on the proven benefits of immuno-nutrition by incorporating the latest in medical research and food science to enhance and accelerate the recovery process. By reducing complications and accelerating the recovery, Proven Recovery® gets patients through their surgical journey faster and safer while simultaneously reducing the cost of healthcare. Proven Recovery® is the only true pharmaco-nutrition product on the market.