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Information for Healthcare Providers
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Please email us at info@proventherapeutics.com
Why Recovery?
Medical science has definitively established the benefits of evidence-based perioperative nutrition on surgical outcomes. Immuno-nutrition (IMN), a specific combination of essential and conditionally essential amino acids with omega-3 fatty acids, has been shown to decrease the incidence of surgical/non-surgical site infections while simultaneously enhancing wound healing and pain relief. These benefits are irrespective of a patient’s baseline nutritional status.
The use of immuno-nutrition is now a consensus recommendation by several major surgical societies and clinical guidelines.
Historically, the barrier to IMN use has been the lack of a palatable, shelf-stable, and convenient. Proven Recovery® has bridged this gap. By combining the evidence of IMN with cutting edge- food science technology, Proven Recovery® can aid in every aspect of patient recovery.
Company Overview
Proven Therapeutics™ is a pharmaconutrition company founded & operated by two Canadian Medical Doctors. Our goal is to provide patients with safe, evidence-based, medical grade nutrition.
Our first-in-class product, Proven Recovery® is a 100% evidence-based pharmaco-nutrition product specifically designed to prepare and improve patients’ recovery from surgery. Proven Recovery® is the only true evidence-based pharmaco-nutrition product on the market.
Each component in Proven Recovery® has been thoroughly researched with the efficacy being verified in multiple human peer-reviewed studies (see bibliography). Proven Recovery® is proudly produced in Canada in a GMP-certified facility where it undergoes third party testing prior to distribution. Proven Recovery® is the only medical grade pharmaco-nutrition supplement that has received:
Evidence-based immuno-nutrition
The evidence that immuno-nutrition improves recovery from surgery is irrefutable1,2,3,4,5,6,7,8.
The medical literature consistently demonstrates that immuno-nutrition lowers the rates of major complications such as infection and prolonged wound healing, while simultaneously accelerating functional outcomes by reducing muscle atrophy and reducing acute and chronic pain. These benefits are realized irrespective of a patient’s pre-existing nutritional status.
Immuno-nutrition has been shown to be beneficial in plastic and reconstructive, oral-maxillofacial, head & neck, orthopaedic, cardiac, cancer, bariatric, trauma, and general surgery.
First-in-class pharmaconutrition
Building on a foundation of immuno-nutrition, Proven Recovery® has gone farther to become a first-in-class evidence-based pharmaconutrition supplement By incorporating the latest in medical research, Proven Recovery® has been designed to specifically target the molecular pathways responsible for multiple aspects of recovery such as muscle atrophy, infection, analgesia, and wound healing.
The Pillars of Recovery represent all the ways in which Proven Recovery® works to accelerate the recovery process.
Pillars of Recovery
Bone
Health
Infection Prevention
Accelerated Recovery
Gut Muscle
Axis
Neural
Protection
Analgesia
Anti-Inflammatory
Wound Healing
Atrophy
Protection
Circadian
Rhythm
Consensus Recommendations
The evidence that immuno-nutrition improves outcomes has become so overwhelming it is now included in the consensus recommendations of major perioperative guidelines9,10,11,12.
“Supplementing with immunonutrition reduces rates of infection and length of stay in patients regardless of their pre-existing nutritional state.”
- Consensus recommendations from American Society for Parenteral and Enteral Nutrition (ASPEN) guidelines
“All patients presenting for major surgery regardless of nutritional status risk take immuno-nutrition for 7 days prior to surgery and for up to 4 weeks after.”
- Duke Perioperative Enhancement Team (POET)
“…strongly recommends immuno-nutrition and recognizes that “arginine-supplemented diets” are associated with a 42% decreased risk of infectious complications. ”
- Strong for Surgery, a pre-habilitation initiative created by the American College of Surgeons
" Malnutrition is among the only major readily modifiable preoperative risk factors associated with poor surgical outcomes…but it is the least diagnosed risk factor.”
“Over 83% of general surgeons believe existing data supports perioperative nutrition to reduce postoperative complications.”
Wischmeyer PE et al., American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Nutrition Screening and Therapy Within a Surgical Enhanced Recovery Pathway. Anesth Analg. 2018 Jun;126(6):1883-1895
Cost Effectiveness
Whether you work in private clinic, or you are a practitioner with a hospital based practice, the routine use of immunonutrition is incredibly effective at reducing costs.
Cost savings are the direct result of decreased complications, length of hospital stay, and readmissions. These savings have been realized in numerous healthcare models across a range of surgeries, patient populations and clinical environments.13,14,15,16
“For every $1 spent on immuno-nutrition a savings of $52.63 was realized.”
Philipson et. al., Impact of oral nutritional supplementation on hospital outcomes. Am J Manag Care. 2013 Feb;19.
“Cost effectiveness of (immuno-nutrition) could be even greater by accounting for the indirect and socioeconomic costs such as sick leave, rehabilitation, and full recovery of physical and social functioning.”
Strickland A., et al. Is the use of specialized nutritional formulations a cost-effective strategy?
A national database evaluation. JPEN J Parenter Enteral Nutr. 2005 Jan-Feb;29.
How to use Proven Recovery®
Proven Recovery® should ideally be started 5 days before surgery and taken for 5 days after.
The product is taken twice a day, in the morning and afternoon, between meals.
Mix 1 scoop of Proven Recovery® with 1-2 cups (250-500ml) of cold water.
Drink immediately after reconstituting and rinse mouth out after use.
For larger procedures (i.e. total joint arthroplasty or laparotomy) it is recommend that two courses of Proven Recovery® be utilized. It should be started 5 days before surgery and taken for 15 days after.
Additional courses can be prescribed at the discretion of the physician. For surgeries specifically associated with decreased postoperative oral intake (i.e. OMF) Proven Recovery® can be started immediately postoperatively.
Which patients should not take Proven Recovery®?
Kidney Disease
As some patients with kidney disease are required to follow a low protein diet, we suggest that patients with renal disease discuss the risk and benefits of taking Proven Recovery® with their physician prior to use.
Pregnancy & Breast feeding
Although not specifically contraindicated, these products have not been tested in pregnancy or lactating women. It is suggested that women who are pregnant or lactating consult with their physician prior to using Proven Recovery®.
People with allergies to fish
Quality Manufacturing
Each component in Proven Recovery® has been thoroughly researched. Safety and efficacy have been verified in multiple human peer-reviewed studies. The final product is produced in Canada in a GMP-certified facility where it is third party tested prior to shipping.
Proven Recovery® has received Health Canada Approval, FDA Clearance and is NSF-Sport certified.
Product Specifications
- Small volume/weight (~340g)
- Flexible polyurethane bag with calibrated scoop included
- Shelf-life stability >2 years
- Small serving size (~18g) to be reconstituted in 250-500ml of water
- Non-genetically modified ingredients, lactose free, daily free, halal, and kosher
Product Components
Non-medical ingredients: Citric Acid 400mg, Calcium citrate 200mg, Magnesium citrate 165mg, Sodium chloride 100mg, Sucralose 150mg, natural flavoring. *Ingredient components/amount/sources subject to change.
Summary
Peri-operative immuno-nutrition has definitively been shown to reduce surgical complications, improve patient outcomes and be a safe, cost-effective approach to improving healthcare.
Proven Recovery® is a first-in-class pharmaconutrition product.
It builds upon the established benefits of immuno-nutrition and incorporates the latest in medical and food science research to enhance and accelerate the recovery process.
By reducing complications and accelerating the recovery, Proven Recovery® gets patients through their surgical journey faster and safer while simultaneously reducing costs.
Proven Recovery® is the only true pharmaco-nutrition product on the market.